The active ingredient in Oxine is Chlorine Dioxide.
*Oxine is on the US EPA's List N of more than 300 disinfectants validated for use against the COVID-19 coronavirus.

At appropriate concentrations, some Chlorine Dioxide disinfectants
can be conveniently sprayed in the air by fine-mist spray bottle or humidifier,
as well as on skin and clothing, to kill viruses, bacteria, mold and fungus.

This makes Chlorine Dioxide extremely valuable since we have learned that COVID-19
can spread through tiny aerosol droplets we breathe out.

You can learn more about Chlorine Dioxide use at

Chlorine dioxide disinfectant for COVID-19 aerosols

How to use Oxine disinfectant for chickens for controlling respiratory sickness caused by viruses, bacteria, fungi or mold
Some bird owners report Oxine AH has been helpful in reducing incidences of some respiratory and other illnesses in their birds.

Caution about effectiveness:

Do not place over-confidence in this treatment. In a number of situations, Oxine is not helpful, so do not have overly high expectations that it will help your birds.
** PoultryPedia does not recommend using Oxine as the primary treatment for most respiratory or other problems, particularly if the problem has developed to a critical point. In many cases, other treatments are needed instead of or in addition to Oxine. **
Note: Using raw, unfiltered apple cider vinegar "with the mother" INSTEAD of Oxine may offer some of the same benefits. However, DO NOT use the two together or they will have a strong chemical reaction.

Oxine AH is a 2% liquid solution of the chemical compound Chlorine Dioxide made by Bio-Cide International. View product information on manufacturer's website.

Oxine kills many types of fungi, as well as Avian Influenza A virus, Newcastle Disease virus, Staphylococcus, Streptococcus, Salmonella, E. Coli, Mycobacterium, and many other bacteria and viruses. However, Oxine can only kill a pathogen if it is used at an appropriate concentration for that pathogen, and it is able to be in direct physical contact with it for a sufficient length of time. (Some require as little as 15 secs. and others require as long as 10 mins.).

Oxine AH comes as a concentrated liquid in a quart or gallon jug. It becomes a much more potent disinfectant when it is "activated" with Citric Acid, which you can order along with your Oxine. Non-activated Oxine requires much higher amounts of concentrate, and still may not be able to reach the same levels of effectiveness.
Caution: Some activation and concentration levels are safe for some types of purposes, but not for others.

Different sources offer conflicting information on using activated vs. unactivated Oxine. You should do additional research to determine correct methods of use.
  • The Oxine bottle label says: You should not use activated Oxine while animals are present, you should use a respirator when spraying, and solution should be washed off feed & water containers before using again.
  • A few other sources say: Activated and non-activated Oxine AH can both be used around, on or in birds, but you need to use more care and cautious dosing if using activated Oxine. You should read additional information on other websites for additional specific recommendations.
    Important note: Some types of uses (such as in drinking water and around food) are only safe with VERY LOW concentrations of Oxine.
  • One source that is considered knowledgeable considers the potency of non-activated Oxine to be so low that it offers very little benefit.
Oxine's effectiveness is deteriorated by exposure to sunlight. Oxine concentrate and all solutions be stored until use in a closed container that is either nontransparent or is kept away from daylight.
  • Activated Oxine solution's effectiveness will decrease over time so you need to usually mix it fresh every 5-10 days.
  • Non-activated Oxine mixed with water will stay effective (although at a lower intensity) a long time.
*Important note: The amount of Oxine required per cup of water is different for making Activated Oxine solutions vs. Non-activated Oxine solutions.

Nebulization / inhaled mist treatment / fogging for Respiratory infections:
Note: Nebulization is an off-label use for Oxine AH, but many poultry keepers report it has helped their birds.
Mix  2 1/2 teaspoons non-activated Oxine AH with 1 cup water. (This is enough for about four 15-min. humidifier or 8 spray bottle treatments for a few chickens.)
* Apply via a fogger, vaporizer, very fine mist spray bottle, an evaporative humidifier, or an ultrasonic "cool mist" humidifier (many of which often produce very small droplets), and direct the mist toward the bird's face.
Note: Water droplets must be very small to reach as deeply as possible into the birds' lungs & air sacs.
~~Tip: You can plug a humidifier into an electrical outlet timer, to set up a cycle of power being turned off & on a few times each day, to provide scheduled Oxine nebulization sessions without you needing to manually run the humidifier.
Directing the mist toward a bird's face can be most conveniently done while it is sleeping on the roost at night, or if you place the bird in a confined area.
* Nice bonus! The mist will also kill bacteria, viruses, fungi and mold on surfaces it lands on in the coop.
  •  For less severe problems: Give one 15+ minute treatment every other day for a week.
  •  For severe problems: Give treatments up to 3 times per day or leave humidifier on overnight for up to 5 days.
  •  Routine care: Give 15-min treatment once a week.
Caution: Do not overdo the heaviness / intensity of the mist! (especially if using spray bottle).
  • Too heavy moisture amounts might make breathing somewhat difficult plus cause too much moisture buildup in lungs and breathing air sacs.
  • With some people, it may be possible for Oxine mist to cause mild temporary headache. It is not known if some birds may experience similar discomfort.
Treatment in drinking water for Digestive Tract infections:
3 to 5 drops (Use eyedropper to add.) non-activated Oxine AH per quart (4 cups) of drinking water.
--Also reduces transmission of germs between birds, plus helps minimize growth of algae in waterer.
* Antibiotic medicines have not been shown to necessarily be incompatible with Oxine, but some may be. It may be best to at least separate them by putting antibiotic in drinking water, and then use Oxine-treated water to moisten food.
* Oxine will kill probiotics such as Lactobacillus, so do not give them together.
* DO NOT USE ORGANIC ACIDS (vinegar, etc.) with Oxine. They react STRONGLY together.
Sanitation and Cleaning
Activated or non-activated Oxine AH can be used to clean contaminated areas. Oxine will kill fungi, and many bacteria and viruses. The activated form has a significantly more potent effect. The manufacturer recommends wearing a face mask respirator in some situations using activated Oxine, though breathing is comfortable where there is good ventilation.
Oxine is VERY SUPERIOR TO BLEACH for cleaning surfaces that have biofilm or are porous..
  • With a bleach solution, bleach's power can get used u itself will stop on any porous surface area (such as wood) and only water will penetrate past that. The water moisture that soaks below the surface can then actually increase growth of fungi, etc.
  • With an Oxine solution, the Oxine will stay with the water and penetrate to also kill fungi, bacteria, etc. below the surface.
Treatment for Infected Wound
Speculation only! Possibly you could experiment with putting diluted non-activated Oxine on a Bumblefoot wound as part of treatment. Oxine kills Staphylococcus aureus, which is the main bacteria that causes most Bumblefoot infections.

* You can order Oxine AH from:
First State Vet Supply, A to Z Vet Supply, Best Veterinary Solutions, Revival Animal Health, Hakes' Twin City Poultry Supplies, Lambert Vet Supply, Great Companions , and Animart .
Several of these retailers also sell the Citric Acid Activator.
Shipping for Oxine is via ground delivery, so it takes a few days & is somewhat expensive because of the weight.
Average costs: 1 gallon of Oxine - $26, shipping - $14.